Netcare 911 paramedics and other services responded to an accident on the N1 south bound before the N12 split.
Upon their arrival on scene they found that a light delivery vehicle transporting people on the back overturned.
Sixteen people were injured during the accident. Two people sustained critical injuries and was airlifted to a Netcare facility by the Netcare1 helicopter and another service provider.
The other people were seriously injured and after being treated and stabilised on scene, they were transported to various hospitals in area for the further medical care.
Exact detail to the cause of the accident and preceding events will remain the subject of a police investigation.