Netcare 911 paramedics and other services responded to an accident on Mimosa Avenue in Proclamation Hill, Pretoria after midnight this morning.
Upon their arrival on scene they found a motor vehicle with four occupants had left the roadway and collided with a tree.
Three people were found to be in a critical condition and one person was found to be in a serious condition.
The Netcare1 helicopter was activated to airlift one of the critically injured people to hospital while the remaining three patients were treated on scene and rushed to hospital for further medical care.
Exact detail to the cause of the accident and preceding events will remain the subject of a police investigation.